The present invention discloses genetically modified plants, such as potato plants. The plants are more resistant to a pathogen of interest following transformation of plant cells with a chimeric gene comprising a chitinase gene and -1,3-glucanase gene. The invention also provides a method of enhancing the resistance of plants to pathogens by introducing a Brassica chitinase gene encoding two or more chitin-binding domains and -1,3-glucanase gene and expressing the chitinase gene and -1,3-glucanase gene.