The invention relates to methods for diagnosing a person's susceptibility
for having an increased risk for the development of atherosclerosis and a
diabetic person's susceptibility for having an increased risk for the
development of diabetic retinopathy. The invention relates further to
methods for treating persons diagnosed for having increased risk for the
development of said diseases, in order to prevent the development of said
diseases. The invention also concerns methods to investigate or screen
pharmaceuticals or genetic aims useful in the treatment of said diseases,
by using an animal model including a transgenic animal.