A catheter system for delivering ultrasonic energy and a therapeutic compound to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end. The catheter system further comprises an inner core configured for insertion into the tubular body. The inner core has an outer surface and comprises an electrically conductive core material. The catheter system further comprises a plurality of ultrasound radiating members positioned on the outer surface of the inner core. The ultrasound radiating members are electrically connected to the electrically conductive core material. The catheter system further comprises an electrically conductive tube-shaped member disposed over the inner core and over the ultrasound radiating members positioned thereon. At least a portion of the electrically conductive tube-shaped member is electrically connected to a plurality of the ultrasound radiating members. The catheter system further comprises control circuitry configured to deliver an input signal to a plurality of the ultrasound radiating members.