The invention is directed to an imidazole derivative represented by formula (1):
##STR1##
wherein each of R1 and R2 represents an aryl group,
a heteroaryl group, etc.; each of A, X1, and X2 represents
N or CH; each of Y and Z represents O, S, etc.; each of R3, R4,
and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number
of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also
directed to a drug containing the derivative or the salt as an active ingredient.
These compounds exert excellent effects of inhibiting production of NO and IL-6
and are useful for preventing or treating diseases induced by overproduction of
NO and IL-6.
