The intervertebral disc is avascular. With aging, nutrients and oxygen transporting through the endplates diminish. The disc degenerates, and pain ensues. Conduits are delivered through a pedicle or vertebral body into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to slow, stop or reverse disc degeneration and relieve pain. Endplate plugs may be deployed to seal gaps between the conduits and the endplates to prevent immune responses to the nucleus pulposus and to preserve the hydrostatic pressure within the disc.