A process for the destruction of vesicants, nerve agents, and related chemical compounds is described. Blister-type chemical agents such as lewisite and mustards, as well as G or V Class nerve agents and phosphorus-containing pesticides, are reacted with a neutralent solution of a persulfate, preferably potassium peroxymonosulfate, and a peroxide, preferably hydrogen peroxide, at temperatures ranging from ambient to boiling for a time sufficient to reduce the residual agent concentration to levels acceptable for disposal in a routine manner.