The present invention provides methods and reagents for detecting antibodies
to adenovirus. In a preferred embodiment, the present invention is useful for detecting
antibodies to adenovirus serotype 5. In a further preferred embodiment, the present
invention can be used in a biosensor-based assay. It is contemplated that the present
invention is useful to detect antibodies for ascertaining adenovirus infection,
evaluating patient response to gene therapy using adenovirus vectors, developing
vaccines to adenovirus infection, developing therapeutics for inducing passive
immunity to adenovirus infection, as well as other uses.