The present invention is directed to non-peptidic factor Xa inhibitors which
are useful for the treatment of arterial and venous thrombotic occlusive disorders,
inflammation, cancer, and neurodegenerative diseases. The factor Xa inhibitors
provide compounds having Formula I:
##STR1##
or pharmaceutically acceptable salts thereof; wherein
- Q is phenyl, benzyl, pyridyl, thienyl, indolyl, quinolinyl, benzothienyl,
biphenylyl, or imidazolyl; any of which can include one or more optional substituents
independently selected from halo, trifluoromethyl, hydroxy, amino, nitro, cyano,
C1 alkoxy, C1-3 alkyl, methylenedioxy, carboxamido, acetamido,
or amidino;
- X is methylene, carbonyl, or sulfonyl; Z is methylene, ethylene, or
propylene; M is methylene or ethylene; and
- R1 R2 and R3 are independently hydrogen
or C1-3 alkyl.
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