Protein kinase, such as CHK-1, inhibiting tricyclic compounds of the following formula (wherein R2, R3 and R4 are as defined in the specification) ##STR1##

pharmaceutical compositions containing effective amounts of said compounds or their salts are useful as a single agent or in combination with an anti-neoplastic agent or therapeutic radiation having an anti-neoplastic effect for treating diseases or conditions such as cancers.

 
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> Lactam-containing compounds and derivatives thereof as factor Xa inhibitors

> Seventeen amino acid peptide (Peptide P) for treating ischemia and reperfusion injury
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