Compounds, compositions and methods are provided for modulating the
expression of Interleukin 12 p35 subunit. The compositions comprise
chemically modified antisense compounds, particularly antisense
oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35
subunit. Methods of using these compounds for modulation of Interleukin
12 p35 subunit expression and for treatment of diseases associated with
expression of Interleukin 12 p35 subunit are provided.