A new and distinct cultivar of Coreopsis plant named 'Crme Brule', characterized by its upright, outwardly spreading and mounded growth habit; very freely basal branching habit; narrow, lacy and bright green-colored foliage; very freely flowering habit with numerous inflorescences per plant; large daisy-type inflorescences; bright yellow-colored ray florets and darker yellow-colored disc florets; long flowering period; and relatively resistant to Powdery Mildew.