The invention concerns a machine for intraoperative radiation therapy or IORT (Intra Operative Radio Therapy), comprising a mobile body, provided with at least two driving wheels (21, 22) and at least an idle wheel (24, 25), each driving wheel (21, 22) being operated by a corresponding moving engine, the machine comprising a radiating head (23) connected to the body, apt to emit am electron beam, the machine being characterised in that it further comprise handling means (19) which are integral with the radiating head (23), engine means for moving the radiating head (23), apt to impress to the radiating head (23) at least a vertical translation motion, said handling means (19) comprising at least three bidirectional sensors (20), apt to measure both a traction stress and a compression stress, each one of which sends to a control processor an electric signal which is proportional to a measured stress which is orthogonal to the sensor, said control processor operating the moving engines of each of said at least two driving wheels (21, 22) and the engine means for moving the radiating head (23) proportionally to the stresses which are measured by said at least three bidirectional sensors (20).