The present invention is a novel soybean cultivar designated CL615261 with high yield potential, tolerance to Roundup.TM. herbicide, mid Group I maturity, tolerance to Iron Deficiency Chlorosis and resistance to Phytophthora Root Rot, further including the plants and seeds of the cultivar CL615261, methods for producing a soybean plant by crossing the cultivar CL615261 with itself or another soybean plant. The invention also relates to soybean cultivar CL615261 further comprising one or more single gene traits, and to methods of producing a soybean having such traits by introgression, transformation or mutagenesis. The invention also includes using the soybean cultivar CL615261 to produce other soybean cultivars, breeding lines, and progeny