The present invention relates to racemic propylisopropyl acetic acid and propylisopropyl
acetamide and their isomers in their racemic and stereospecific forms, for use
in treatment of neurological and psychotic disorders, and affective disorders and
to treat pain, headaches and migraines. The isomers are of the compound formula
I
##STR1##
- R1 is a methyl or ethyl group;
- R2 is H, methyl or an ethyl group;
- R3 is ethyl or a propyl group; and
- R4 is a hydroxyl or amide group,
and the total number of carbon atoms in said compound is 8, provided that when
R1 is a methyl group and R4 is an amide group, R2 and R3 are not ethyl, further
provided that when R1 is an ethyl and R4 a hydroxyl group, only stereoisomers of
the compound are referred to.
The present invention further relates to a method for the stereoselective synthesis
of the 2R stereoisomer of PID and PIA. The present invention also relates to pharmaceutical
compositions containing as an active ingredient a racemic mixture or stereoisomers
of the compounds of the general formula (I), which are useful for the treatment
of neurological and psychotic disorders, and affective disorders and to treat pain,
headaches and migraines.
|
|
|
