A multi-function telephone handset comprises a handset body on which is defined a receiving space, and a holding element to which is mounted a receiver and a transmitter. Two opposite portions of the handset body are respectively formed in a receiver part and a transmitter part respectively provided with sound holes. The holding element, with the receiver and the transmitter thereto connected, is detachably placed in the receiving space of the handset body. The telephone handset can be thereby configured to in a manner to perform either a conventional telephonic communication by manually holding the telephone handset, or a hand-free telephonic communication can be achieved by carrying the holding element on the user's head.