Novel parathyroid hormone (PTH) polypeptide derivatives are disclosed, as
are pharmaceutical compositions containing said polypeptides, and
synthetic and recombinant methods for producing said polypeptides. Also
disclosed are methods for treating mammalian conditions characterized by
decreases in bone mass using therapeutically effective pharmaceutical
compositions containing said polypeptides. Also disclosed are methods for
screening candidate compounds of the invention for antagonistic or
agonistic effects on parathyroid hormone receptor action. Also disclosed
are diagnostic and therapeutic methods of said compounds.