The present invention provides methods and devices for treating the annulus of an intervertebral disc. The methods and devices can employ an expandable treatment device which is deployed at least partially in the subannular space. Fixation devices and methods are also disclosed, which help to secure the treatment device in place.


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> Inhibition of protein kinase C-related kinase (PRK) as a treatment for cardiac hypertrophy and heart failure

> Prosthesis with feature aligned to trabeculae

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