This invention relates to N-acylamino aryl derivatives of the formula 1
where
R.sup.1R.sup.21, R.sup.22, R.sup.23, R.sup.24, R.sup.3, R.sup.4, R.sup.5,
R.sup.6, R.sup.7, R.sup.8, R, and
n are as defined herein and where
X is --CHRO, --OCHR--, --CH.sub.2S--, --SCH.sub.2--, --CH.sub.2CH.sub.2--,
--CH.dbd.CH-- or --C.ident.C--.
The compounds of the invention are selective monoamine oxidase B
inhibitors, and they are therefore useful in the treatment of diseases
mediated by monoamine oxidase B, for example, for the treatment of
Alzheimer's disease or senile dementia.
