A seal structure for an inner-shaft bearing of a front-wheel drive vehicle includes an inner-shaft interconnecting a differential gear to a drive shaft for achieving balance between a left wheel drive shaft and a right wheel drive shaft. An inner-shaft bearing is assembled to the inner shaft and sealed with an inner seal member. A bracket is connected to the vehicle body and fixed to the circumference of the inner-shaft bearing for supporting the inner-shaft. A first dust cover is inserted to the inner-shaft for enclosing one end of the bracket, and a second dust cover is inserted to the drive shaft for enclosing the other end of the bracket.