An inflatable inner sole for footwear has a flexible, inflatable enclosure with an inflation system that preferably includes an on-board air pump and a pressure relief valve. This embodiment has an additional upper chamber formed by heat sealing (welding) an outer layer of thermoplastic on top of an inflatable enclosure. The outer layer is preferably bonded only to the edges of the inflatable enclosures to permit free air/fluid flow from pressure points area to the area of least resistance and greatest need. Air pressure of the lower chamber can be adjusted according to a wearer's weight and activities. The upper chamber also has a built-in air pump and relief valve, preferably with lesser air pressure that can be adjusted according to the wearers foot problems or for final comfort tuning. The outer layer may be a laminated material of thermoplastic film, foam and fabric.