A soybean cultivar, designated SO22206, is disclosed. The invention relates to the seeds of soybean cultivar SO22206, to the plants of soybean SO22206 and to methods for producing a soybean plant produced by crossing the cultivar SO22206 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar SO22206 with another soybean cultivar.