A method, computer program product, and information handling system for generating loop code to execute on Single-Instruction Multiple-Datapath (SIMD) architectures, where the loop operates on datatypes having different lengths, is disclosed. Further, a preferred embodiment of the present invention includes a novel technique to efficiently realign or shift arbitrary streams to an arbitrary offset, regardless whether the alignments or offsets are known at the compile time or not. This technique enables the application of advanced alignment optimizations to runtime alignment. This allows sequential loop code operating on datatypes of disparate length to be transformed ("simdized") into optimized SIMD code through a fully automated process.