A novel soybean cultivar, designated 03022253, is disclosed. The invention relates to the seeds of soybean cultivar 03022253, to the plants of soybean 03022253 and to methods for producing a soybean plant produced by crossing the cultivar 03022253 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar 03022253 with another soybean cultivar.