The invention relates to substituted alcohol compounds of the formula (I):
##STR1##
wherein X, R1, R2, R3, RN, R20
and RC are defined herein. The compounds are useful in the treatment
or prevention of Alzheimer's disease and more specifically to compounds that are
capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor
protein to produce amyloid beta peptide (A-beta), a major component of the amyloid
plaques found in the brains of Alzheimer's sufferers.