Some embodiments of the invention provide a method of defining a global route for a net in a region of a layout, where each net has a set of routable elements. The method partitions the region into several rectangular sub-regions. It then identifies a set of sub-regions that contain the routable elements of the net. Next, it defines a global route that connects the identified sub-regions, where the global route includes at least one non-Manhattan edge that crosses a boundary between two sub-regions at a non-vertex location.