The present invention relates to pyrimidinedione derivatives of following formula
(I) which are useful as antiviral agents, especially as agents for treatment of
AIDS, pharmaceutically acceptable salts thereof, process for the preparation thereof
and pharmaceutical compositions containing the same, wherein R represents cyclopropyl;
cyclobutyl; cyclohexyl; unsubstituted or mono-, di- or trisubstituted phenyl with
a group selected from hydroxy, C1-C4 alkyl, C1-C4
alkoxy, halogen, trifluoromethyl, cyano and amino; 1- or 2-naphthyl; 9-anthracenyl;
2-anthraquinonyl; unsubstituted or substituted pyridyl with a group selected from
C1-C4 alkyl, C1-C4 alkoxy, cyano and
halogen; 2-, 3- or 4-quinolinyl; oxiranyl; 1-benzotriazolyl; 2-benzoxazolyl; furanyl
substituted with C1-C4 alkoxycarbonyl; C1-C4
alkylcarbonyl; or benzoyl, R1 represents halogen or C1-C4
alkyl, R2 and R3 represent independently hydrogen or
C1-C4 alkyl, X represents oxygen atom, and Y represents oxygen
atom, sulfur atom or carbonyl.
