This invention describes novel pyrazole compounds of formula IIc:
##STR1##
wherein R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic
ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl
or carbocyclyl; Rx and Ry are taken together with their intervening
atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring
having 0-3 heteroatoms; and R2 and R2 are as described
in the specification. The compounds are useful as protein kinase inhibitors, especially
as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes
and Alzheimer's disease.