A method, computer system and set of signals are disclosed allowing for communication of a data transfer, via a bus, between a master and a slave using a single transfer request regardless of transfer size and alignment. The invention provides three transfer qualifier signals including: a first signal including a starting byte address of the data transfer; a second signal including a size of the data transfer in data beats; and a third signal including a byte enable for each byte required during a last data beat of the data transfer. The invention is usable with single or multiple beat, aligned or unaligned data transfers. Usage of the three transfer qualifier signals provides the slave with how many data beats it will transfer at the start of the transfer, and the alignment of both the starting and ending data beats. As a result, the slave need not calculate the number of bytes it will transfer. In terms of multiple beat transfers, the number of data transfer requests are reduced, which reduces the amount of switching, bus arbitration and power consumption required. In addition, the invention allows byte enable signals to be used for subsequent data transfer requests prior to the completion of the initial data transfer, which reduces power consumption and allows for pipelining of data transfer requests.