Human Papillomavirus virus like particles (VLPs) have been constructed so that
they contain a modified L2 protein. The L2 protein has been minimized and is fused
to a second protein or peptide. The fused protein is incorporated into the VLP
and the VLP can deliver the protein to a cell. The modified VLPs can be used to
increase the breadth of immune response in vaccine preparations or to deliver other
proteins of interest.