Segmentation of pulmonary nodules from digital volumetric image includes segmenting, automatically, the pulmonary nodule from attached anatomical structures by analyzing a structure of interest, and providing a template according to an analyzed structure of interest, wherein the template displays a segmentation of a volume of interest including an object of interest. The template can be adjusted according to a one or more adjustable parameters. The method stores values of the parameters according to the object of interest, and stores a segmentation of the object of interest according to the values of the parameters. The segmentation is refined by extracting and labeling surrounding anatomical structures, defining each structure touching a boundary of a volume of interest as an elongated object, determining a size and shape for each structure, and determining a distance of a current structure to the segmentation result, upon determining the distance to be small compared to a threshold.