Low density microspheres, methods for preparing same, and use of same as contrast
agents are described. The microspheres have a void having a volume that comprises
at least about 75% of the total volume of the microspheres, and which contains
a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic
hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.