Arylpyrazine compounds are provided, including arylpyrazines that can
bind with high affinity and high selectivity to CRF1 receptors, including
human CRF1 receptors. The invention thus includes methods for treatment
of disorders and diseases associated with CRF1 receptors, including
CNS-related disorders and diseases, particularly affective disorders and diseases,
and acute and chronic neurological disorders and diseases.