A method and a device provide for the registration of two 3D image data sets of an object to be examined. The object to be examined is provided with a plurality of markers In order to enable a registration to be carried out, the positions of the markers in the 3D image data sets are first determined in a co-ordinate system associated with the relevant 3D image data set. The distances between the markers and/or the angles formed between lines which intersect in a marker and extend through two further markers are then determined. Finally, a transformation rule for the transformation of one of the 3D image data sets to the co-ordinate system of the other 3D image data set is determined.