A cotton cultivar, designated DP 6222 RR Acala, is disclosed. The invention relates to the seeds of cotton cultivar DP 6222 RR Acala, to the plants of cotton DP 6222 RR Acala and to methods for producing a cotton plant produced by crossing the cultivar DP 6222 RR Acala with itself or another cotton variety. The invention also relates to methods for producing a cotton plant containing in its genetic material one or more transgenes and to the transgenic cotton plants and plant parts produced by those methods. This invention also relates to cotton cultivars or breeding cultivars and plant parts derived from cotton variety DP 6222 RR Acala, to methods for producing other cotton cultivars, lines or plant parts derived from cotton cultivar DP 6222 RR Acala and to the cotton plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar DP 6222 RR Acala with another cotton cultivar.