The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified.

 
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< Pharmacophore recombination for the identification of small molecule drug lead compounds

< Medical implant processing chamber

> Screen for selective inhibitors or activators of Smad protein function

> Focused acoustic energy in the preparation of peptide arrays
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