The present invention relates to eglin c variants which inhibit proteases, and
in particular to eglin c mutants at adventitious contact sites. The present invention
also relates to eglin c variants which comprise mutations in both adventitious
contact sites and at reactive loop sites. The present invention further relates
to methods of preparing the eglin c variants, and methods of using the eglin c
variants for treatment of diseases including acute bacterial, viral, and fungal infections.