A compound having the general structure shown in Formula 1: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK.sub.1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.

 
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> Substituted 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazine derivatives and their use as neurokinin antagonists
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