The present invention provides novel nucleic acid and protein sequences for methods
and compositions for treating, screening, and diagnosing cardiovascular disease
and methods for using these genes and gene products for prevention of cardiac cell
death and prevention of cardiac tissue damage resulting from ischemic events in
cardiac tissue, as well as other tissue that is subject to damage resulting from
an ischemic event. The genes, gene products and agents of the invention are also
useful for treating other related clinical or coronary events such as angina, myocardial
infarct (MI), and stroke, for monitoring the effectiveness of their treatment,
and for drug development. The genes, gene products and agents of the present invention
are also provided as pharmaceutical compositions for treatment of cardiovascular
disease, ischemic heart disease, myocardial infarct and related conditions. Kits
are also provided for the diagnosis, treatment and prognosis of cardiac diseases
and related conditions.