The present invention relates to new quinoline derivatives of formula (1) or
their pharmaceutically acceptable salts with caspase-3 inhibitory activity and
their preparation methods, wherein R2 is H; halogen; C1-6alkyl;
C1-6 alkoxy; C1-6 alkoxyalkyl; or C3-6cycloalkyl;
R1 is formula (a); —CN; or formula (b); R is H; C6-14aryl
unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy
or amino; 5-15 membered heterocyclic group unsubstituted or substituted by halogen,
C1-6 alkyl, C1-6 alkoxy or amino; or —(CH2)n—CHR4R5.
The present invention relates to a pharmaceutical composition for treating caspase-associated
diseases by inhibiting the activity of caspase-3 which comprises the compound of
formula (1) or its pharmaceutically acceptable salt.
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