Activation of peroxisome proliferator activated receptor alpha (PPAR.alpha.) by administration of therapeutic amounts of a PPAR.alpha. agonist, WY-14643, inhibits the proliferation of vascular smooth muscle cells, hepatoma cells and human renal proximal tubule cells. WY-14643 may be applicable as a medicament for the treatment of proliferative vascular disease (atherosclerosis, hypertension), revascularization-induced injury (restenosis) and chronic renal failure.

 
Web www.patentalert.com

< Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders

< Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes by increasing the number of islets of langerhans cells

> Aryloxyalkylamine derivatives as h3 receptor ligands

> Novel modulators of the PPAR-type receptors and cosmetic/pharmaceutical compositions comprised thereof

~ 00245