The present invention relates to ion channel modulating agents. More particularly,
the present invention relates to a particular class of chemical compounds that
has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further
aspects, the present invention relates to the use of these SK/IK/BK channel modulating
agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical
compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel
modulating agents of the invention are useful for the treatment or alleviation
of diseases and conditions associated with the SK/IK/BK channels.