The present invention relates to the delivery of headache and anti-migraine compounds
through an inhalation route. Specifically, it relates to aerosols containing that
are used in inhalation therapy. In a method aspect of the present invention, rizatriptan
or zolmitriptan is administered to a patient through an inhalation route. The method
comprises: a) heating a composition, comprising rizatriptan or zolmitriptan to
form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation
aerosol with less than 5% of the drug degradation products. In a kit aspect of
the present invention, a kit for delivering rizatriptan or zolmitriptan through
an inhalation route is provided which comprises: a) a thin coating of a rizatriptan
or zolmitriptan composition; and, b) a device for dispending said thin coating
as a condensation aerosol.