A disk drive includes a data storage disk, a transducer, a micro actuator, a coarse actuator, and a controller. The micro actuator is configured to position the transducer relative to the disk over a first range of movement. The coarse actuator is configured to position the micro actuator relative to the disk over a second range of movement that is larger than the first range of movement. The controller is configured to control positioning of the transducer by the coarse actuator and the micro actuator in a track following operation, and in a seek operation responsive to a seek command. The controller is also configured to calibrate its positioning of the transducer by the micro actuator responsive to receipt of the seek command and prior to seeking the transducer from an initial track to a target track.