The device (10) for manual control of a surgical guide (G) comprises a body (12) provided with a conduit (14) for passage of the surgical guide (G), and a member (16) for axially immobilizing the surgical guide relative to the body. The member (16) is displaceable between a position in which it immobilizes the surgical guide and a position in which it releases the surgical guide. Said immobilizing member (16) is made integral with the body (12).