The present invention is directed to a system and method for providing a collaborative integration of hybrid electronic and micro and sub-micro, including nano, level aggregates. A method of sampling aggregate nano behavior to determine progress by the nano aggregate toward a desired result may include sampling at least one of aggregate nano and aggregate micro behavior by a transducer. The aggregate behavior is measured through use of the sample by a macro level control apparatus. If the measured aggregate behavior is identified as diverging from progress toward a desired result, an effector is activated by the macro level control apparatus to influence the aggregate behavior toward progress toward the desired result.