The present invention discloses non-catechol compounds, such as thiazolothiazepines, and analogs and derivatives thereof, which are anti-integrase inhibitors. The compounds, which are useful as treatments for HIV disease, include compounds (I), (II), (III), or pharmaceutically acceptable salts thereof wherein A is thiazole, benzene, naphthalene, pyridine, pyrimidine, pyrazine, or quinoline; R is one or more of H, halogen, lower alkyl, lower alkoxy, NO₂, lower ester or carboxylic acid; X—Y is CH₂—S, S—CH₂, CH₂—O, CH₂—S(O). S(O)—CH₂, CH₂—CH₂, CH₂—CH₂—CH₂, or CH₂—CH₂—CH₂—CH₂; R₄ is H or hydroxy; R₅ is H, phenyl, or alkylamine; W is S or O; and R₆ is H, substituted or unsubstituted alkyl or amine; and Z is S, O, CH₂, CH₂CH₂, or CO.