A process for instabilizing viral quasi-species-distributions under avoidance
of
resistance phenomena by replication of the nucleic acids of the viruses present
in the quasi-species-distribution by of a defective replication system,
- a)
- whereby the defective replication system has a rate of misincorporation
for nucleotides above the rate of misincorporation of the viral wild-type-replication
system and,
- whereby the viruses are replicated by the replication system having
the higher rate of misincorporation at least as effectively as it is done by the
replication system of the wild-type virus,
- b)
- and/or negative influence of the replication of the consensus-sequence
(nucleic acid sequence of the wild-type virus) in relation to other replicatable
nucleic acids.