The present invention is generally directed to Matrimony (Mtrm) nucleotide
sequences, polypeptides expressed from the nucleotide sequences and
methods employing the Mtrm nucleotide and polypeptide sequences. The Mtrm
nucleotide sequences of the invention express a dosage dependent
polypeptide that mediates achiasmate chromosome disjunction. In
particular, reduction in the amount of the Mtrm polypeptide will cause
nondisjunction in the achiasmate chromosomes.