The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15
protein. Also provided is a vector capable of expressing the DNA of the present
invention adapted for expression in a recombinant cell and regulatory elements
necessary for expression of the DNA in the cell. The present invention further
provides for methods of inhibiting TADG-15 expression and/or protease activity,
methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15
inhibitors. Additionally, the present invention provides for cell-specific targeting
via TADG-15 and methods of vaccinating an individual against TADG-15. The instant
invention also includes a kit containing antibodies for the detection of TADG-15
protein. The methods described are useful in the diagnosis, treatment and prevention
of cancer, particularly breast and ovarian cancer.