The present invention provides novel tricyclic diazepine compounds and methods
and pharmaceutical compositions utilizing them for the treating or preventing disorders
including diabetes insipidus, nocturnal enuresis, nocturia, urinary incontinence,
bleeding and coagulation disorders, congestive heart failure or for inducing temporary
delay of urination, and in conditions with increased vascular resistance and coronary
vasoconstriction; and for the treating or preventing disorders remedied or alleviated
by oxytocin antagonist activity, including suppression of preterm labor, dysmenorrhea,
endometritis, and for suppressing labor at term prior to caesarean delivery. These
compounds are also useful in enhancing fertility rates, enhancing survival rates
and synchronizing estrus in farm animals; and treatment of disfunctions of the
oxytocin system in the central nervous system including obsessive compulsive disorder
(OCD) and neuropsychiatric disorders.